ラテン語のmusculus、mouse、muscleが語源で、語源的にはmouseと同じ。筋肉の膨らみが跳躍するネズミに似ているという古代の信仰から名付けられた。
Musclez & lacertez bene one selfe ting, Bot te muscle is said to te fourme of mouse & lacert to te fourme of a lizard. [Guy de Chauliac, "Grande Chirurgie," c. 1425]Hence muscular and mousy are relatives, and a Middle English word for "muscular" was lacertous, "lizardy." Figurative sense of "force, violence, threat of violence" is 1930, American English. Muscle car "hot rod" is from 1969.